Undergraduate Lab Safety |
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University of California - MSDS System PAGE 1
02/08/96
Source of MSDS: FISHER SCIENTIFIC CORPORATION
MATERIAL SAFETY DATA SHEET
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FISHER SCIENTIFIC EMERGENCY NUMBER USA: (201) 796-7100
CHEMICAL DIVISION CHEMTREC ASSISTANCE: (800) 424-9300
1 REAGENT LANE CANADA: (613) 226-8874
FAIR LAWN, NJ 07410
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SUBSTANCE IDENTIFICATION
CAS NUMBER: 67-63-0
RTECS NUMBER: NT8050000
SUBSTANCE: **2-PROPANOL**
TRADE NAMES/SYNONYMS:
ISOPROPANOL; LUTOSOL; PETROHOL; DIMETHYLCARBINOL; IPA; AVANTIN; PROPAN-2-OL;
ALCOSOLVE 2; AVANTINE; ISOPROPYL ALCOHOL; ALCOJEL; ISOHOL; N-PROPAN-2-OL;
SEC-PROPYL ALCOHOL; PRO; STCC 4909205; UN 1219;
A415; A416; A417; A426; A419; A432; A451; A519; A520; A451SK; A416SK;
A426P; A464; A516; C3H8O;
CHEMICAL FAMILY:
Hydroxyl, aliphatic
MOLECULAR FORMULA: C3-H8-O
MOLECULAR WEIGHT: 60.11
CERCLA RATINGS (SCALE 0-3): HEALTH=3 FIRE=3 REACTIVITY=0 PERSISTENCE=0
NFPA RATINGS (SCALE 0-4): HEALTH=1 FIRE=3 REACTIVITY=0
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COMPONENTS AND CONTAMINANTS
COMPONENT: 2-PROPANOL PERCENT: 100
CAS# 67-63-0
OTHER CONTAMINANTS: NONE
EXPOSURE LIMITS:
ISOPROPYL ALCOHOL (ISOPROPANOL; 2-PROPANOL):
400 ppm (983 mg/m3) OSHA TWA; 500 ppm (1230 mg/m3) OSHA STEL
400 ppm (983 mg/m3) ACGIH TWA; 500 ppm (1230 mg/m3) ACGIH STEL
400 ppm (983 mg/m3) NIOSH recommended 10 hour TWA;
500 ppm (1230 mg/m3) NIOSH recommended STEL
400 ppm (983 mg/m3) DFG MAK TWA;
800 ppm (1966 mg/m3) DFG MAK 30 minute peak, average value, 4 times/shift
Measurement method: Charcoal tube; 2-butanol/carbon disulfide; gas
chromatography with flame ionization detection; (NIOSH III # 1400,
Alcohols I).
Subject to SARA Section 313 Annual Toxic Chemical Release Reporting
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02/08/96
(only persons who manufacture by the strong acid process are subject,
supplier notification not required.)
**OSHA revoked the final rule limits of January 19, 1989 in response to the
11th Circuit Court of Appeals decision (AFL-CIO v. OSHA) effective
June 30, 1993. See 29 CFR 1910.1000 (58 FR 35338)**
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PHYSICAL DATA
DESCRIPTION: Transparent, colorless, mobile liquid with a characteristic mild
alcoholic odor and a slightly bitter taste. BOILING POINT: 180 F (82 C)
MELTING POINT: -129 F (-89 C) SPECIFIC GRAVITY: 0.785 VOLATILITY: 100%
VAPOR PRESSURE: 40 mmHg @ 23.8 C EVAPORATION RATE: (butyl acetate=1) 2.88
SOLUBILITY IN WATER: soluble ODOR THRESHOLD: 50 ppm VAPOR DENSITY: 2.1
SOLVENT SOLUBILITY: Soluble in ethanol, ether, chloroform, acetone,
benzene; insoluble in salt solutions.
VISCOSITY: 2.1 cP @ 25 C
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FIRE AND EXPLOSION DATA
FIRE AND EXPLOSION HAZARD:
Dangerous fire hazard when exposed to heat or flame.
Vapors are heavier than air and may travel a considerable distance to a source
of ignition and flash back.
Vapor-air mixtures are explosive above flash point.
FLASH POINT: 53 F (12 C) (CC) UPPER EXPLOSIVE LIMIT: 12.7% @ 93 C
LOWER EXPLOSIVE LIMIT: 2.0% AUTOIGNITION TEMP.: 750 F (399 C)
FLAMMABILITY CLASS(OSHA): IB
FIREFIGHTING MEDIA:
Dry chemical, carbon dioxide, water spray or alcohol-resistant foam
(1993 Emergency Response Guidebook, RSPA P 5800.6).
For larger fires, use water spray, fog or alcohol-resistant foam
(1993 Emergency Response Guidebook, RSPA P 5800.6).
Alcohol foam
(NFPA 325M, Fire Hazard Properties of Flammable Liquids, Gases, and Volatile
Solids, 1991).
FIREFIGHTING:
Move container from fire area if you can do it without risk. Apply cooling
water to sides of containers that are exposed to flames until well after fire
University of California - MSDS System PAGE 3
02/08/96
is out. Stay away from ends of tanks. For massive fire in cargo area, use
unmanned hose holder or monitor nozzles; if this is impossible, withdraw from
area and let fire burn. Withdraw immediately in case of rising sound from
venting safety device or any discoloration of tank due to fire. Isolate for
1/2 mile in all directions if tank, rail car or tank truck is involved in fire
(1993 Emergency Response Guidebook, RSPA P 5800.6, Guide Page 26).
Extinguish only if flow can be stopped; use water in flooding amounts as fog,
solid streams may not be effective. Cool containers with flooding quantities
of water, apply from as far a distance as possible. Avoid breathing toxic
vapors, keep upwind.
Water may be ineffective (NFPA 325M, Fire Hazard Properties of Flammable
Liquids, Gases, and Volatile Solids, 1991)
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TRANSPORTATION DATA
U.S. DEPARTMENT OF TRANSPORTATION SHIPPING NAME-ID NUMBER, 49 CFR 172.101:
Isopropyl alcohol-UN 1219
U.S. DEPARTMENT OF TRANSPORTATION HAZARD CLASS OR DIVISION, 49 CFR 172.101:
3 - Flammable liquid
U.S. DEPARTMENT OF TRANSPORTATION PACKING GROUP, 49 CFR 172.101:
PG II
U.S. DEPARTMENT OF TRANSPORTATION LABELING REQUIREMENTS, 49 CFR 172.101
AND SUBPART E:
Flammable liquid
U.S. DEPARTMENT OF TRANSPORTATION PACKAGING AUTHORIZATIONS:
EXCEPTIONS: 49 CFR 173.150
NON-BULK PACKAGING: 49 CFR 173.202
BULK PACKAGING: 49 CFR 173.242
U.S. DEPARTMENT OF TRANSPORTATION QUANTITY LIMITATIONS 49 CFR 172.101:
PASSENGER AIRCRAFT OR RAILCAR: 5 L
CARGO AIRCRAFT ONLY: 60 L
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TOXICITY
ISOPROPYL ALCOHOL (ISOPROPANOL; 2-PROPANOL):
IRRITATION DATA: 500 mg skin-rabbit mild; 100 mg eye-rabbit severe; 10 mg
eye-rabbit moderate; 100 mg/24 hours eye-rabbit moderate.
TOXICITY DATA: 16000 ppm/4 hours inhalation-rat LCLo; 12800 ppm/3 hours
inhalation-mouse LCLo; 8000 ppm/8 hours/20 weeks-intermittent
inhalation-rat TCLo; 12800 mg/kg skin-rabbit LD50; 5272 mg/kg oral-man LDLo;
14432 mg/kg oral-man TDLo; 3570 mg/kg oral-human LDLo; 223 mg/kg
oral-human TDLo; 13 gm/kg oral-infant TDLo; 5045 mg/kg oral-rat LD50;
3600 mg/kg oral-mouse LD50; 6410 mg/kg oral-rabbit LD50; 1537 mg/kg
oral-dog LDLo; 6 gm/kg subcutaneous-mammal LDLo; 6 gm/kg subcutaneous-mouse
LDLo; 1088 mg/kg intravenous-rat LD50; 1509 mg/kg intravenous-mouse LD50;
1184 mg/kg intravenous-rabbit LD50; 1963 mg/kg intravenous-cat LDLo;
1024 mg/kg intravenous-dog LDLo; 2735 mg/kg intraperitoneal-rat LD50; 4477
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mg/kg intraperitoneal-mouse LD50; 667 mg/kg intraperitoneal-rabbit LD50;
2560 mg/kg intraperitoneal-guinea pig LD50; 3444 mg/kg
intraperitoneal-hamster LD50; 2770 mg/kg unreported-man LDLo; mutagenic
data (RTECS); reproductive effects data (RTECS).
CARCINOGEN STATUS: Human Inadequate Evidence, Animal Inadequate Evidence
(IARC GROUP-3). Strong acid manufacturing process: Human Sufficient Evidence
(IARC Group-1). Workers involved in the manufacture of isopropyl alcohol by
the strong-acid process, involving the formation of isopropyl oils, showed
an increase in paranasal and laryngeal cancer.
LOCAL EFFECTS: Irritant- inhalation, eye.
ACUTE TOXICITY LEVEL: Slightly toxic by dermal absorption and ingestion.
TARGET EFFECTS: Central nervous system depressant.
AT INCREASED RISK FROM EXPOSURE: Persons with pre-existing skin disorders;
impaired liver, renal and/or pulmonary function.
ADDITIONAL DATA: Potentiates the effect of carbon tetrachloride and
other hepatotoxic chlorinated aliphatic hydrocarbons.
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HEALTH EFFECTS AND FIRST AID
INHALATION:
ISOPROPYL ALCOHOL (ISOPROPANOL; 2-PROPANOL):
IRRITANT/NARCOTIC. 2000 ppm Immediately Dangerous to Life or Health.
ACUTE EXPOSURE- Human subjects exposed to 400 ppm for 3-5 minutes had mild
irritation of the nose and throat. At 800 ppm the irritation was not
severe but uncomfortable. Higher concentrations may cause effects
as detailed in acute ingestion. The length of time required to produce
deep narcosis in animals was inversely proportional to the concentration:
The onset of deep narcosis ranged from 460 minutes at 3250 ppm to
100 minutes at 24,500 ppm.
CHRONIC EXPOSURE- Mice subjected to 10900 ppm isopropyl alcohol in air for
about 4 hours/day until they had accumulated 123 hours of exposure were
narcotized but survived. Reversible fatty changes were observed in the
liver. Male mice exposed to either 1000 or 5000 ppm of isopropyl alcohol
vapor for 6 hours a day for 9 exposures exhibited hyaline droplet
nephropathy. Reproductive effects have been reported in animals. There
has been an increased incidence of cancer of the paranasal sinuses,
and possibly of the larynx, in the manufacture of isopropyl alcohol
by the strong acid process, involving the formation of isopropyl oils.
It is not clear which substances are responsible.
FIRST AID- Remove from exposure area to fresh air immediately. Perform
artificial respiration if necessary. Keep person warm and at rest. Treat
symptomatically and supportively. Get medical attention immediately.
SKIN CONTACT:
ISOPROPYL ALCOHOL (ISOPROPANOL; 2-PROPANOL):
NARCOTIC.
ACUTE EXPOSURE- Contact with the skin may cause slight irritation. Contact
dermatitis has been reported in a few sensitive individuals. Substance
may be dermally absorbed resulting in systemic toxicity as detailed in
acute ingestion. Toxic effects may become more marked if absorption
and inhalation occur concurrently.
CHRONIC EXPOSURE- Repeated or prolonged exposure may cause dermatitis due
to the defatting action on the skin. Repeated and prolonged exposure to
the skin of rabbits caused slight erythema, drying, and superficial
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02/08/96
desquamation.
FIRST AID- Remove contaminated clothing and shoes immediately. Wash with
soap or mild detergent and large amounts of water until no evidence of
chemical remains (at least 15-20 minutes). Get medical attention
immediately.
EYE CONTACT:
ISOPROPYL ALCOHOL (ISOPROPANOL; 2-PROPANOL):
IRRITANT.
ACUTE EXPOSURE- 400-800 ppm may cause irritation. In rabbit eyes, a drop
caused mild transitory injury and a 50% aqueous solution after 3 minutes
caused moderate irritation. Contact with a 70% solution caused
conjunctivitis, iritis, and corneal opacity.
CHRONIC EXPOSURE- Prolonged or repeated exposure to vapors may cause
conjunctivitis.
FIRST AID- Wash eyes immediately with large amounts of water or normal saline,
occasionally lifting upper and lower lids, until no evidence of chemical
remains (at least 15-20 minutes). Get medical attention immediately.
INGESTION:
ISOPROPYL ALCOHOL (ISOPROPANOL; 2-PROPANOL):
NARCOTIC.
ACUTE EXPOSURE- Ingestion may cause abdominal pain, hematemesis, nausea,
vomiting, and hemorrhage. Central nervous system depression may occur with
headache, dizziness, flushing, incoordination, stupor, confusion,
hypotension, areflexia, and refractory narcosis. Oliguria followed by
diuresis and coma may also occur. Other symptoms may include
hypoglycemia, tenderness and edema of muscles, and arrhythmias. Vomiting
with aspiration may cause aspiration pneumonia. Depressed respiration
and death due to respiratory paralysis may occur in a few hours after
exposure. Severe and prolonged shock may lead to serious or fatal renal
damage after several days. Pathologic findings have included extensive
hemorrhagic tracheobronchitis, bronchopneumonia and hemorrhagic pulmonary
edema.
CHRONIC EXPOSURE- No adverse effects resulted in humans following daily
ingestion of 2.6 and 6.4 mg/kg for 6 weeks. Rats that ingested 0.5 to
10.0% isopropyl alcohol in drinking water for 27 weeks showed decreased
body weight. Prolonged oral administration in rabbits produced anesthesia
and death. Reproductive effects have been reported in animals.
FIRST AID- In respiratory depression, give oxygen by artificial respiration.
Give activated charcoal. Gastric lavage with protected airway is useful
even if delayed. Do not attempt emesis if respiration is depressed.
Maintain blood pressure. Treatment should be administered by qualified
medical personnel (Dreisbach, Handbook of Poisoning, 12th Ed.). Get medical
attention.
ANTIDOTE:
No specific antidote. Treat symptomatically and supportively.
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REACTIVITY
REACTIVITY:
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02/08/96
ISOPROPYL ALCOHOL (ISOPROPANOL; 2-PROPANOL):
Stable under normal temperatures and pressures. May slowly peroxidise on
exposure to air under normal storage conditions. An explosion hazard may
exist if the substance is distilled or allowed to evaporate to dryness.
INCOMPATIBILITIES:
ISOPROPYL ALCOHOL (ISOPROPANOL; 2-PROPANOL):
ACIDS: Incompatible.
ACIDS ANHYDRIDES: Incompatible.
ALUMINUM: Dissolution is exothermic.
BARIUM PERCHLORATE: Formation of explosive compound.
2-BUTANONE (METHYL ETHYL KETONE): Accelerates the peroxidation of the
alcohol.
CHROMIUM TRIOXIDE (GRANULAR): Ignition.
COATINGS: May be attacked.
DIOXYGENYL TETRAFLUOROBORATE: Ignition at ambient temperatures.
HALOGENS: Incompatible.
HYDROGEN + PALLADIUM (PARTICLES): Ignition on exposure to air.
HYDROGEN PEROXIDE: Formation of explosive compound.
KETONES: Markedly increases the possibility of peroxidation.
NITROFORM (TRINITROMETHANE): Dissolves liberating heat and possibly
exploding.
OLEUM: Temperature and pressure increase in closed container.
OXIDIZERS (STRONG): Fire and explosion hazard.
OXYGEN (GAS): Autoxidation, on exposure to light, results in formation of
ketones and potentially explosive hydrogen peroxide.
PHOSGENE: In the presence of iron salts, may explode.
PLASTICS: May be attacked.
POTASSIUM TERT-BUTOXIDE: Ignition.
RUBBER: May be attacked.
SODIUM DICHROMATE + SULFURIC ACID: Exothermic reaction with possible
incandescence.
See also alcohols.
DECOMPOSITION:
Thermal decomposition products may include toxic oxides of carbon.
POLYMERIZATION:
Hazardous polymerization has not been reported to occur under normal
temperatures and pressures.
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STORAGE AND DISPOSAL
Observe all federal, state and local regulations when storing or disposing
of this substance.
**Storage**
Preserve in tight containers, remote from heat. (U.S. Pharmacopeia, national
formulary, 1985).
Store in accordance with 29 CFR 1910.106.
Bonding and grounding: Substances with low electroconductivity, which
University of California - MSDS System PAGE 7
02/08/96
may be ignited by electrostatic sparks, should be stored in containers
which meet the bonding and grounding guidelines specified in NFPA 77-1983,
Recommended Practice on Static Electricity.
Store away from incompatible substances.
**Disposal**
Disposal must be in accordance with standards applicable to generators of
hazardous waste, 40 CFR 262. EPA Hazardous Waste Number D001.
100 pound CERCLA Section 103 Reportable Quantity.
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CONDITIONS TO AVOID
Avoid contact with heat, sparks, flames, or other sources of ignition. Vapors
may be explosive and poisonous; do not allow unnecessary personnel in area.
Do not overheat containers; containers may violently rupture and travel a
considerable distance in heat of fire.
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SPILL AND LEAK PROCEDURES
OCCUPATIONAL SPILL:
Shut off ignition sources; no flares, smoking or flames in hazard area. Stop
leak if you can do it without risk. Water spray may reduce vapor; but it may
not prevent ignition in closed spaces. For small spills, take up with sand or
other noncombustible absorbent material and place into containers for later
disposal. For larger spills, dike far ahead of spill for later disposal. Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep
out of low areas.
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PROTECTIVE EQUIPMENT
VENTILATION:
Provide general dilution ventilation to meet published exposure limits.
Ventilation equipment must be explosion-proof.
RESPIRATOR:
The following respirators and maximum use concentrations are recommendations
by the U.S. Department of Health and Human Services, NIOSH Pocket Guide to
Chemical Hazards; NIOSH criteria documents or by the U.S. Department of
Labor, 29 CFR 1910 Subpart Z.
The specific respirator selected must be based on contamination levels found
in the work place, must not exceed the working limits of the respirator and
be jointly approved by the National Institute for Occupational Safety and
Health and the Mine Safety and Health Administration (NIOSH-MSHA).
ISOPROPYL ALCOHOL:
2000 ppm- Any supplied-air respirator operated in a continuous-flow
mode.
Any chemical cartridge respirator with a full facepiece and
organic vapor cartridge(s).
Any air-purifying, full facepiece respirator (gas mask) with
University of California - MSDS System PAGE 8
02/08/96
a chin-style, front- or back-mounted organic vapor
canister.
Any powered, air-purifying respirator with organic vapor
cartridge(s).
Any self-contained breathing apparatus with a full
facepiece.
Any supplied-air respirator with a full facepiece.
Escape- Any air-purifying, full facepiece respirator (gas mask) with
a chin-style, front- or back-mounted organic vapor
canister.
Any appropriate escape-type, self-contained breathing
apparatus.
FOR FIREFIGHTING AND OTHER IMMEDIATELY DANGEROUS TO LIFE OR HEALTH CONDITIONS:
Any self-contained breathing apparatus that has a full facepiece and is
operated in a pressure-demand or other positive-pressure mode.
Any supplied-air respirator that has a full facepiece and is operated in a
pressure-demand or other positive-pressure mode in combination with an
auxiliary self-contained breathing apparatus operated in pressure-demand
or other positive-pressure mode.
CLOTHING:
Employee must wear appropriate protective (impervious) clothing and equipment
to prevent repeated or prolonged skin contact with this substance.
GLOVES:
Employee must wear appropriate protective gloves to prevent contact with this
substance.
EYE PROTECTION:
Employee must wear splash-proof or dust-resistant safety goggles to prevent
eye contact with this substance.
Emergency eye wash: Where there is any possibility that an employee's eyes may
be exposed to this substance, the employer should provide an eye wash
fountain within the immediate work area for emergency use.
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COPYRIGHT 1984-1995 MDL INFORMATION SYSTEMS, INC. ALL RIGHTS RESERVED.
CREATION DATE: 02/26/85 REVISION DATE: 07/10/95
-ADDITIONAL INFORMATION-
THE ABOVE INFORMATION IS BELIEVED TO BE ACCURATE AND REPRESENTS THE BEST
INFORMATION CURRENTLY AVAILABLE TO US. HOWEVER, WE MAKE NO WARRANTY OF
MERCHANTABILITY OR ANY OTHER WARRANTY, EXPRESSED OR IMPLIED, WITH RESPECT TO
SUCH INFORMATION, AND WE ASSUME NO LIABILITY RESULTING FROM ITS USE. USERS
SHOULD MAKE THEIR OWN INVESTIGATIONS TO DETERMINE THE SUITABILITY OF THE
INFORMATION FOR THEIR PARTICULAR PURPOSES.
Other Safety Resources can be found on the internet.
Perhaps the Best Source for
Material Safety Data Sheets On-line is at
the University of Vermont at:
http://siri.org/msds
Undergraduate Lab Safety |
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